The following case studies offer accounts of individual patients and the events detected by their Guardian implants. These patients have not participated in the ALERTS clinical study.

Detection and Confirmation of Progressive Plaque Burden (IMD #2662) ST Trend Alert Resulting in Stent Event: +ST Shift	Detection and Confirmation of Progressive Plaque Burden (IMD #2326) ST Trend Alert Resulting in Stent Event: ST Trend
Rapid Detection and Confirmation of Occluded LCX Due to Ruptured Plaque (IMD #338) ST Elevation Resulting in CABG Event: +ST Shift	Detection and Confirmation of Progressive Plaque Burden (IMD #952) ST Depression Resulting in Stent Event: -ST Shift

Rapid Detection and Confirmation of Occluded LAD Due to Ruptured Plaque (IMD #376) ST Trend Alert Resulting in Stent Event: -ST Shift	Rapid Detection and Confirmation of Occluded RCA Due to Ruptured Plaque (IMD #164) ST Elevation Resulting in Stent Event: +ST Shift
Detection of Demand-Induced Persistent Ischemia(IMD #158) Prolonged ST Depression Resulting in LCX Stent Event: -ST Shift